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high importance~2 Q in Tier 14 formulas⚡ 12 shortcuts6 subtopics

Human body — organs, blood, digestion, glands

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Record-holders of the human body

FactAnswer
Largest organSkin
Largest gland / largest internal organLiver
Longest boneFemur (thigh bone)
Smallest boneStapes (middle ear)
Bones in an adult206 (about 300 at birth; many fuse)
Strongest/hardest substanceTooth enamel
Master glandPituitary
Largest part of the brainCerebrum
Functional unit of the kidneyNephron
Structural and functional unit of the nervous systemNeuron
Normal body temperature37 °C (98.6 °F)
Normal blood pressureAbout 120/80 mm Hg
Normal resting heart rateAbout 72 beats per minute

Blood and circulation

  • William Harvey described the circulation of blood.
  • RBCs carry oxygen with haemoglobin (iron-containing), live about 120 days, are made in red bone marrow; the spleen is the 'graveyard of RBCs'. WBCs fight infection (immunity). Platelets help clotting.
  • Blood groups — Karl Landsteiner (ABO). O is the universal donor (O negative, strictly) and AB the universal recipient (AB positive, strictly). The Rh factor was also found by Landsteiner and Wiener (named after the rhesus monkey).
  • The human heart has 4 chambers; the SA node is the natural pacemaker. Arteries carry blood away from the heart (all oxygenated except the pulmonary artery); veins carry blood to the heart (all deoxygenated except the pulmonary vein).

Digestion

WhereSecretion / enzymeAction
MouthSalivary amylase (ptyalin)Starch → maltose
StomachHCl + pepsinKills germs; proteins → peptides
LiverBile (stored in the gall bladder)Emulsifies fats — contains no enzyme
PancreasTrypsin, lipase, amylaseProteins, fats, starch
Small intestineVilliMost absorption of digested food
Large intestine—Absorbs water
  • The small intestine is the longest part of the alimentary canal.

Nervous and endocrine systems

  • Cerebrum — intelligence, memory, voluntary actions. Cerebellum — balance and coordination. Medulla oblongata — involuntary actions (heartbeat, breathing, swallowing).
GlandHormoneNote
PituitaryGrowth hormone and others'Master gland'
ThyroidThyroxine (needs iodine)Deficiency → goitre
Pancreas (islets of Langerhans)Insulin (β-cells), glucagon (α-cells)Insulin lowers blood sugar; lack → diabetes mellitus
AdrenalAdrenaline'Fight or flight' hormone
Testes / ovariesTestosterone / oestrogen, progesteroneSex hormones
  • The pancreas is both an endocrine and an exocrine gland. Insulin was isolated by Banting and Best (1921).
  • In the eye, the retina holds the image; the cornea is what is donated in eye donation.
  • The lungs' air sacs (alveoli) are the site of gas exchange.

Detailed notes

Body records — the standard list

RecordAnswer
Largest organSkin
Largest gland / largest internal organLiver
Largest endocrine glandThyroid
Longest boneFemur (thigh)
Smallest boneStapes (middle ear)
Smallest muscleStapedius (ear)
Strongest muscle (by force)Jaw (masseter)
Bones in an adult206
Bones in a newbornabout 300 (many fuse later)
Ribs12 pairs = 24
Normal body temperature37 °C (98.6 °F)

Blood and circulation

Blood ≈ 5 litres. Plasma (55%, the liquid), RBC (oxygen on haemoglobin), WBC (defence), platelets (clotting). Blood groups: ABO + Rh; O− is the universal donor, AB+ the universal recipient. The heart has 4 chambers (2 atria + 2 ventricles); its natural pace-maker is the SA node; humans have double circulation (blood passes through the heart twice per loop). Blood pressure is measured with a sphygmomanometer; normal ≈ 120/80 mm Hg. A resting heart beats ≈ 72 times a minute.

Digestive system — organ by organ

Mouth: salivary amylase starts starch digestion. Stomach: HCl + pepsin (protein); a mucous lining saves the stomach from itself. Liver makes bile (stored in the gall bladder — no enzymes, it only emulsifies fat). Pancreas sends trypsin (protein) and lipase (fat). The small intestine is the real digestion + absorption site (villi); the large intestine absorbs only water.

Endocrine glands — hormones

Pituitary = 'master gland' (growth hormone; under- or over-secretion gives dwarfism/gigantism). Thyroid = thyroxine (contains iodine) — deficiency causes goitre; pancreas = insulin (from the islets of Langerhans) controls blood sugar — its failure is diabetes; adrenal = adrenaline (the 'fight-or-flight' hormone); testes/ovaries = testosterone/estrogen.

Excretion and the brain

Kidneys filter the blood in about a million nephrons each; urine (urea + water + salts) reaches the bladder. The brain: cerebrum (thinking, largest part), cerebellum (balance, posture), medulla oblongata (involuntary heartbeat/breathing — a spine injury there is fatal); reflex actions are handled by the spinal cord without waiting for the brain.

Quick revision

  • 206 adult bones; stapes smallest, femur longest; skin largest organ; liver largest gland.
  • O− universal donor, AB+ universal recipient; SA node = pace-maker; BP 120/80 (sphygmomanometer).
  • Bile has no enzymes (emulsifies fat); HCl + pepsin in stomach; villi absorb in the small intestine.
  • Pituitary master gland; thyroxine needs iodine; insulin from pancreas fights diabetes; adrenaline = fight-or-flight.
  • Cerebrum thinks, cerebellum balances, medulla keeps the heart beating.

Types of questions asked

Every way this subtopic shows up in exams — how to recognise it, the formula or logic to use, and a solved example.

Type 1: Body records (largest/smallest/number)very common4 practice Q
How to spot it:

'Largest gland / largest organ / longest bone / smallest bone', 'how many bones does an adult have', 'which muscle is the smallest', number-of-ribs questions.

  1. Records: skin = largest organ; liver = largest gland (and largest internal organ); thyroid = largest ENDOCRINE gland; femur = longest bone; stapes = smallest bone; stapedius = smallest muscle.
  2. Numbers: adult 206 bones, newborn ≈ 300, ribs 12 pairs.
  3. Trap: 'largest gland' = liver; 'largest endocrine gland' = thyroid; both are often mixed. Why: pure recall — keep one list, test the three largest-X pairs against each other.

Example: The smallest bone in the human body is —

Stapes in the middle ear (about 3 mm). The smallest muscle, stapedius, sits right beside it.

Type 2: Blood, groups and circulationvery common4 practice Q
How to spot it:

'Universal donor / recipient', 'which blood cells fight infection / help clotting', 'pace-maker of the heart', 'how many chambers does the heart have', instrument for BP.

  1. Cells: RBC carry oxygen; WBC defend; platelets clot.
  2. Groups: O− universal donor; AB+ universal recipient; Rh factor decides +/−.
  3. Heart: 4 chambers; SA node = pace-maker; double circulation in humans.
  4. BP instrument = sphygmomanometer; normal 120/80 mm Hg; pulse ≈ 72/min resting.

Example: Which blood group is the universal recipient?

AB+ — it carries no anti-A or anti-B antibodies. O− is the universal donor counterpart.

Type 3: Organ ↔ secretion/functionvery common4 practice Q
How to spot it:

'Insulin is secreted by…', 'bile is produced in… / stored in…', 'which organ filters the blood', 'HCl is secreted in…', 'nephron belongs to…'.

  1. Digestive secretions: mouth–salivary amylase; stomach–HCl + pepsin; liver–bile (stored in gall bladder, no enzymes); pancreas–trypsin + lipase (+ insulin from islets of Langerhans).
  2. Kidney: filtration unit = nephron; brain parts: cerebrum–thinking, cerebellum–balance, medulla–involuntary control.
  3. 'Bile stored where' = gall bladder; 'bile made where' = liver — split them.

Example: Bile, which helps digest fats, is produced by the —

Liver (largest gland) and stored in the gall bladder; it emulsifies fat but contains no enzymes.

Type 4: Hormone ↔ gland and deficiencyvery common3 practice Q
How to spot it:

'Insulin / thyroxine / adrenaline is secreted by', 'master gland', 'which hormone controls blood sugar', 'deficiency of growth hormone causes…'.

  1. Master gland–pituitary (growth hormone); thyroid–thyroxine (iodine; low → goitre); pancreas–insulin (diabetes); adrenal–adrenaline (fight-or-flight).
  2. Sex hormones: testes–testosterone, ovaries–estrogen.
  3. Link each hormone to its imbalance: dwarfism/gigantism–growth hormone, goitre–thyroxine, diabetes–insulin. Why: gland–hormone–disease is a fixed triangle; any corner can be asked.

Example: Which gland is called the 'master gland'?

Pituitary — its hormones steer the other endocrine glands, including the thyroid and adrenals.

Type 5: Digestion steps and enzymescommon2 practice Q
How to spot it:

'Which enzyme digests protein / starch / fat', 'where is food fully digested and absorbed', 'function of villi', 'which juice has no enzyme', 'peristalsis is…'.

  1. Enzyme-to-food: amylase–starch, pepsin/trypsin–protein, lipase–fat.
  2. Small intestine = final digestion + absorption (villi increase area); large intestine = water only.
  3. Bile = no enzymes, emulsifies fat; peristalsis = wave-like muscle movement pushing food.

Example: Digested food is absorbed mainly in the —

Small intestine, through millions of villi that multiply the absorbing surface. The large intestine takes up only water and salts.

Type 6: Body numbers (computed)common2 practice Q
How to spot it:

'How many times does the heart beat in a day', 'normal body temperature in °F', 'how much blood does an adult have', questions needing 72 × 60 or 37 → 98.6 conversion.

  1. Heart: 72 beats/min → 72 × 60 × 24 = 103,680 beats/day.
  2. Temperature: 37 °C = 98.6 °F (F = 9C/5 + 32).
  3. Blood volume ≈ 5 litres; RBC count ≈ 5 million/mm³; WBC ≈ 6,000–8,000/mm³.
  4. Compute the arithmetic in your head by splitting: 72 × 60 = 4,320; × 24 ≈ 1.04 lakh.

Example: At a resting rate of 72 beats per minute, the heart beats about how many times a day?

72 × 60 × 24 = 103,680 — roughly 1 lakh beats a day, pumping thousands of litres.

Formulas

Body mass index
BMI=mass (kg)height (m)2\text{BMI} = \frac{\text{mass (kg)}}{\text{height (m)}^{2}}

18.5–24.9 is the normal range (WHO)

Shortcut tricks

⚡ Blood group giving: 'O gives, AB takes'

O has no A/B antigens → can give to all. AB has no anti-A/anti-B antibodies → can take from all.

Example: The universal recipient blood group is?

AB.

⚡ Brain parts: 'Cerebrum thinks, Cerebellum balances, Medulla keeps you alive'

Thinking/memory — cerebrum; balance/posture — cerebellum; heartbeat/breathing — medulla oblongata.

Where students lose marks

  • Saying bile contains digestive enzymes — it only emulsifies fats.

  • Answering thyroid for the master gland — it is the pituitary.

  • Naming the heart or liver as the largest organ — skin is the largest organ; liver is the largest gland/internal organ.

Practice sets — 22 questions

Sets of 10, mixed across the question types above. Each answer comes with a step-by-step explanation.

Topic test · 10 questions

Suggested time 3 min · wrong answers go to your mistake notebook automatically.